Lipid Balance

Promotes healthy cholesterol levels and is cardio-protective

Clinical Applications

• Multidimensional Support for Optimizing Cardiovascular Health (can assist in high cholesterol and coronary artery disease)
• Preserves Arterial Health and Elasticity (can assist in hypertension)
• Supports Healthy CoQ-10 Levels (can assist if on statin therapy)
• Supports Healthy Levels of Fasting Glucose, Leptin, and Ghrelin (can assist in insulin resistance)

Lipid Balance contains Bergamot BPF which is a powerful and unique array of cholesterol-balancing and cardio-protective polyphenolic flavonoids. Cholesterol can be consumed through food, but circulating cholesterol levels are primarily produced and controlled by the liver using an enzyme, HMG-CoA reductase (HMGCR). Because of its pronounced role in cholesterol synthesis, inhibiting HMGCR has become a primary target of many traditional therapies. Numerous clinical trials have shown Bergamot BPF works at the level of the liver to help maintain and support healthy cholesterol levels plus preserve coronary arteries by maintaining normal inflammatory balance.1 Recent studies have also shown Bergamot BPF can help maintain healthy levels of fasting glucose, leptin, and ghrelin which are important in controlling appetite and satiety after eating.2-11

References

1.Gliozzi M, Walker R, Muscoli S, Vitale C, Gratteri S, Carresi C, Musolino V, Russo V, Janda E and Ragusa S. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. International journal of cardiology. 2013;170:140-145.

2. Di Donna L, Iacopetta D, Cappello AR, Gallucci G, Martello E, Fiorillo M, Dolce V and Sindona G. Hypocholesterolaemic activity of 3-hydroxy-3-methyl-glutaryl flavanones enriched fraction from bergamot fruit (Citrus bergamia):“In vivo” studies. Journal of Functional Foods. 2014;7:558-568.

3. Campolongo G, Riccioni CV, Raparelli V, Spoletini I, Marazzi G, Vitale C and Volterrani M. The combination of nutraceutical and simvastatin enhances the effect of simvastatin alone in normalising lipid profile without side effects in patients with ischemic heart disease. IJC Metabolic & Endocrine. 2016;11:3-6.

4. Cappello A, Dolce V, Iacopetta D, Martello M, Fiorillo M, Curcio R, Muto L and Dhanyalayam D. Bergamot (Citrus bergamia Risso) Flavonoids and Their Potential Benefits in Human Hyperlipidemia and Atherosclerosis: an Overview. Mini reviews in medicinal chemistry. 2015.

5. Giglio RV, Patti AM, Nikolic D, Volti GL, Al-Rasadi K, Katsiki N, Mikhailidis DP, Montalto G, Ivanova E and Orekhov AN. The effect of bergamot on dyslipidemia. Phytomedicine. 2015.

6. Janda E, Lascala A, Martino C, Ragusa S, Nucera S, Walker R, Gratteri S and Mollace V. Molecular mechanisms of lipidand glucose-lowering activities of bergamot flavonoids. PharmaNutrition. 2016.

7. Mollace V, Ragusa S, Sacco I, Muscoli C, Sculco F, Visalli V, Palma E, Muscoli S, Mondello L and Dugo P. The protective effect of bergamot oil extract on lecitine-like oxyLDL receptor-1 expression in balloon injury-related neointima formation. Journal of cardiovascular pharmacology and therapeutics. 2008;13:120-129.

8. Risitano R, Currò M, Cirmi S, Ferlazzo N, Campiglia P, Caccamo D, Ientile R and Navarra M. Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes. PLoS One. 2014;9:e107431.

9. Trombetta D, Cimino F, Cristani M, Mandalari G, Saija A, Ginestra G, Speciale A, Chirafisi J, Bisignano G and Waldron K. In vitro protective effects of two extracts from bergamot peels on human endothelial cells exposed to tumor necrosis factor-α (TNF-α). Journal of agricultural and food chemistry. 2010;58:8430-8436.

10. Benson J. ALTERNATIVE MEDICINE CABINET: Bergamot. Alternative Medicine. 2015:49. 13. Capomolla AS, Janda E, Paone S, et al. Atherogenic Index Reduction and Weight Loss in Metabolic Syndrome Patients Treated with A Novel Pectin-Enriched Formulation of Bergamot Polyphenols. Nutrients. 2019;11(6):1271. Published 2019 Jun 4. doi:10.3390/nu11061271.