DHEA 25 MG - 90 CT ME

Hormone balancing and stress-fighting

Clinical Applications

• Promotes Healthy Hormonal Balance (can assist with low hormone levels)
• Supports Mood Regulation (can assist in mood swings related to abnormal cortisol levels)
• Balances the Stress Response System by Improving Cortisol-to-DHEA Ratios (can assist in chronic stress)
• Maintains Healthy Aging and Normal Inflammatory Balance
• Supports Bone Health

Dehydroepiandrosterone (DHEA) is a steroid hormone precursor secreted primarily by the adrenal glands, which helps maintain healthy hormone levels and helps support the stress response system. DHEA functions as the counterpart to the stress hormone cortisol. Maintaining healthy DHEA levels is crucial for balancing the catabolic effects of cortisol.

DHEA and its sulfate, DHEAs, are the most abundant steroid hormones in the human body and can be found in blood, saliva, urine and cerebrospinal fluid (CSF).1 DHEA serves as a “buffer” reservoir to be used for the intracellular synthesis of various estrogens and androgens throughout the human body. DHEA production peaks during the second decade of life, and then DHEA levels typically decline by 10% per decade. In addition to the normal decline associated with aging, other possible causes of a decline in DHEA production include inflammation, blood sugar imbalances, and long-term stress.

Elevated cortisol levels can play a major role in normal mood regulation. DHEA counterbalances high levels of cortisol and brightens mental outlook. DHEA can easily cross the blood-brain barrier, and supplementation with DHEA has been shown to support mood regulation by increasing levels of β-endorphins, quieting glutamate receptors and protecting against the effects of glucocorticoids in the brain.2,3

DHEA functions as a precursor for the formation of estradiol and androgens, which promotes healthy bone formation by increasing levels of insulin-like growth factor. In a double-blind, placebo-controlled trial, DHEA supplementation of 50 mg/day improved bone turnover and decreased osteoclast activity in women older than 70 years. 4 An additional randomized placebo-controlled trial of 225 healthy women (ages 55 to 85 years) showed that oral dosing of 50 mg/day of DHEA for one year showed

positive effects on markers of bone health.5

DHEA has been shown to maintain normal inflammatory balance by inhibiting the activation of nuclear factor-kβ and the secretion

of inflammatory compounds such as IL-6 and IL-2 which can benefit patients with gastrointestinal (GI) challenges/diseases.6

Research has indicated that DHEA naturally supports healthy aging by reversing classic stress-induced physiological responses. It has been found that in elderly men, those with the highest DHEA levels had the highest level of functioning.7 An additional study found that oral doses of 50 mg of DHEA per day supported bone health, libido, and improved skin health in participants over 70 years of age.4

DHEA is a precursor to estrogen and testosterone. It also has receptors present in human muscle cells. Clinical studies using oral doses of DHEA have demonstrated women (ages 50-65 years) receiving 25mg/day for 12 months, DHEA promoted hormonal balance as soon as 3 months of DHEA administration. As indicated by serum concentrations, DHEA helped support healthy levels of testosterone, progesterone, estrone and estradiol.8

Each capsule provides 25 mg of DHEA derived from the wild yams.

References:

2. Wolkowitz OM, Reus VI, Roberts E, et al. Dehydroepiandrosterone (DHEA) treatment of depression. Biol Psychiatry. 1997;41:311-318.

3. Genazzani AR, Stomati M, Bernardi F, et al. Dehydroepiandrosterone as neurosteroid: neuroendocrine effects in post-menopausal women. J Endocrinol Invest. 1999;22 (suppl 10):19-23.

4. Baulieu EE, Thomas G, Legrain S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Prov Natl Acad Sce USA. 2000;97:4279-4284.

5. Von Muhlen D, Laughlin GA, Kritz-Silverstein D, et al. Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers and body composition in older adults: the DAWN trial. Osteoporos Int. 2008;19:699-707.

6. Straub RH, Konecna L, Hrach S, et al. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interlukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J Clin Endocrinol Metab. 1998;83:2012-2017.

7. Ravaglia G, Forti P, Maioli F, et al. The relationship of dehydroepiandrosterone sulfate (DHEA) to endocrinemetabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninetyyear-olds. J Clin Endocrinol Metab. 1996; 81:1173-1178.

8. Genazzani AD, Stomati M, Bernardi F, et al. Long-term low-dose dehydroepiandrosterone and oral supplementation in early and late postmenopausal women modulates endocrine parameters and synthesis of neuroactive steroids. Fertil Steril. 2003;80:1495- 1501.