Supports, protects, and preserves cartilage, tendons, ligaments, fascia, intervertebral discs, and skin
Clinical Applications
- Protects and Promotes Connective Tissue Biosynthesis
- Supports Joint Lubrication, Joint Cushioning, and Normal Connective Tissue Inflammatory Response (can assist in joint pain or osteoarthritis pain)
- Supports the Body’s Processes of Cartilage, Tendon, Ligament and Fascia Self-Repair (can assist in joint trauma, athletes, or weight lifters)
- Supports Normal Rejuvenation of Healthy Hair, Skin and Nails (can assist in hair loss, hair thinning, brittle nails, or anti aging)
Collagen is a crucial element of skin and connective tissues. This protein is responsible for giving skin a youthful bounce, and as it declines, so does skin appearance and overall connective tissue health. Over time, lifestyle factors can cause reduced elasticity in cartilage, tendons, ligaments and skin. This leads to wrinkles, decreased dermal matrix strength, and soft tissue and joint discomfort. Collagen is formulated to nutritionally support cartilage, tendons, ligaments, fascia and skin.1-3
Modern Endocrine's Collagen includes three clinically studied ingredients (FORTIGEL®, Tendaxion® and Mobilee®) to support the natural healing process and maintain connective tissue structure. Most therapies simply block joint pain and connective tissue discomfort from exercise, and inhibit the regeneration and elongation of specific polysaccharide precursors.
FORTIGEL®, backed by more than fifteen studies, provides bioactive collagen peptides (BCPs), which contain high concentrations of specific peptides that comprise connective tissue. The precise length of the short-chain peptides and low average molecular weight allows easy absorption, transport, and accumulation to target connective tissue. It provides 5 g hypoallergenic protein per serving from a sustainable protein source. The lower dose of collagen peptides decreases excess oxalate production, compared to higher-dose collagen and gelatin products. One randomized, double-blind, placebo-controlled clinical trial performed in cooperation with Harvard Medical School demonstrated FORTIGEL® showed significant improvement in hyaline cartilage and proteoglycan content in participants’ knee joints at 24 weeks and 48 weeks suggesting a potential to stimulate an effective chondrocyte response to maintain the collagenous matrix.4 A 2021 clinical study of 180 young adults supplemented with this over 12 weeks had a significant reduction in joint pain from exercise.5
Mobilee® is a patented rooster comb extract rich in high molecular weight hyaluronic acid (HA), which is responsible for the viscoelastic, lubricating properties of synovial fluid. This extract also contains collagen and other glycosaminoglycans (GAGs). Scientific evidence shows Mobilee® supports chondrocytes and synovial cell function, and is two to four times more active than regular HA in supporting synovial fluid health.6-7 It also supports the quality of synovial fluid by positively influencing synovial HA concentration, and by reducing the expression of degradative factors in synovial fluid.8-10
Tendaxion® is a combination of type I collagen and mucopolysaccharides. Adult tendons, ligaments and fascial tissue are comprised mainly of type I collagen molecules organized into structural units. The molecular structure and organization of tendon, ligament and fascial collagen fibrils are key determinants in the ability of these tissues to endure mechanical force and fuel self-repair. While collagen provides much of tendon/ligament structure and strength, mucopolysaccharides are the “glue” that holds them together and allows them to stretch, flex, bend and maintain their resilience. Mucopolysaccharides are a critical component of extracellular matrix and are important in maintaining structural integrity, lubrication and spacing of collagen fibers.11-14
References
1. Oesser S, Adam M, Babel W, Seifert J: Oral administration of 1 4C labelled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). Journal of Nutrition, 129 (1999), 1891 – 1895 12).
2. Oesser S, Seifert J: Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res 311 (2003), 393 – 399.
3. Moskowitz RW: Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism. Vol.30, No. 2 (October 2000), 87 – 99 18).
4. McAlindon TE, Nuite M, Krishnan N, Ruthazer R, et al. Changes in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial. Osteoarthritis and Cartilage 19 (2011) 399e405.
5. Zdzieblik, D.; Brame, J.; Oesser, S.; Gollhofer, A.; König, D. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial. Nutrients 2021, 13, 523.
6.Torrent A, Ruhí R, Theodosakis J, et al. Comparative efficacy of IB0004, extracted hyaluronic acid (HA) and fermented HA on the synthesis of endogenous HA by human synoviocytes. Osteoarthritis Cartilage. 2009;17(Suppl 1):S278-79. – 10x HA secretion.
7. Torrent A, Ruhí R, Martínez C, et al. Anti-inflammatoryactivity and absorption of a natural rooster comb extract. Osteoarthritis and Cartilage. 2010 Oct;18(Suppl 2):S246- 47. doi:10.1016/S1063-4584(10)60577-8. – reduction of inflammation.
8. Möller I, Martinez-Puig D, Chetrit C. Oral administration of a natural extract rich in hyaluronic acid for the treatment of knee OA with synovitis: a retrospective cohort study. Clinical Nutrition Supplements 2009;4(2):171-172.
9. Martinez-Puig D, Möller I, Fernández C, Chetrit C. Efficacy of oral administration of yoghurt supplemented with a preparation containing hyaluronic acid (Mobilee™) in adults with mild joint discomfort: a randomized, double-blind, placebo controlled intervention study. Mediterranean Journal of Nutrition and Metabolism 2013;6:63–68.
10. Sánchez J, Bonet ML, Keijer J, v an Schothorst EM, Mölller I, Chetrit C, Martinez-Puig D, Palou A. Blood cells transcriptomics as source of potential biomarkers of articular health improvement: effects of oral intake of a rooster combs extract rich in hyaluronic acid. Genes & Nutrition 2014; 9: 417.
11. Nadal et al. Effectiveness of treatment of tendinitis and plantar fascitis by TENDAXION®. Osteoarthritis and Cartilage 2009; 17(1):S253.
12. Arquer et al. The efficacy and safety of oral mucopolysaccharide, type I collagen and vitamin C treatment in tendinopathy patients Apunts Med Esport. 2014;49:31-6.
13. Balius et al. A Randomized, Placebo-Controlled Study to Evaluate Efficacy and Safety of A Dietary Supplement Containing Mucopolysaccharides, Collagen Type I and Vitamin C for Management of Different Tendinopathies Ann Theum Dis. 2014;73, Suppl. 2:299-300.
14. Proksch E, Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27(3):113-9. doi:10.1159/000355523
