Helps maintain balanced blood sugar levels which can also help promote weight loss
Clinical Applications
- Provides Key Nutrients for Blood Sugar Regulation (can assist with insulin resistance, pre-diabetes, and diabetes)
- Helps Maintain Healthy Blood Sugar Levels (can assist with hypoglycemia)
- Balances Blood Sugar and Insulin Levels which Regulates Energy Production (can assist with fatigue and weight loss)
- Supports Normal Cellular Metabolism
Recent studies also show that 93% of Americans are metabolically unhealthy, and a large majority of this is due to insulin resistance. Maintaining healthy blood sugar (glucose) levels can often pose a challenge because, on average, Americans spend 21 hours a day being sedentary.1 Additionally, we consume foods that are highly processed, refined, and contain excessive levels of sugar.2 Combining these lifestyle practices with genetic predisposition and high stress patterns make it very difficult to maintain adequate blood sugar levels.
Healthy blood sugar regulation is a complex process that requires a number of metabolic factors working at optimal capacity. Part of this process includes a balance between glucagon and insulin, which are hormones secreted by the pancreas. If blood glucose levels fall (which occurs due to stress or lack of food intake for an extended period of time), pancreatic alpha cells secrete glucagon, a hormone that triggers the release of stored glucose (glycogen) from the liver and skeletal muscles for energy. Conversely, when blood sugar levels are elevated, beta cells in the pancreas secrete insulin. Insulin causes liver cells, muscle cells and fat cells to take up glucose from the bloodstream and store this as energy. Over time, too much insulin can be secreted due to unhealthy lifestyle choices leading to insulin resistance and weight gain. The delicate balance of blood sugar and insulin levels are crucial for regulating the body’s production of energy. Micronutrients such as chromium and biotin are required to support enzymatic reactions and cellular signaling systems that maintain the body’s homeostasis.
Insulin Impact is a natural and synergistic formula for maintaining balanced blood sugar. Through enhanced signaling at the cellular level, the blend of natural extracts and vitamins in Insulin Impact support healthy blood glucose levels. It contains:
Alpha lipoic acid (ALA), which is a nutrient required for cellular metabolism, specifically the breakdown of carbohydrates and fatty acids.3
Cinnamon in the form of Cinnulin® which acts by inhibiting several enzymes that play a role in insulin resistance leading to an increase in insulin sensitivity.4,5
Chromium which is a part of the molecule glucose tolerance factor (GTF). GTF is a complex crucial for the uptake of glucose into the cells.6,7 Studies using 1000 mcg/day of chromium have demonstrated this helps maintain healthy blood sugar balance, insulin sensitivity and blood lipids.8
Biotin which is a B vitamin that plays a major role in energy production by acting as a coenzyme for carboxylase enzymes involved in the metabolism of fatty acids and amino acids.17,18 Biotin also plays numerous roles in maintaining healthy blood sugar balance by, stimulating insulin secretion, enhancing insulin sensitivity, accelerating glucose metabolism in the liver and pancreas, and increasing the number of insulin secreting beta cells in the pancreas. 11, 12
Vanadyl sulfate (VS) is the stable, inorganic form of vanadium, a mineral shown to mimic the action of insulin. VS causes activation of GLUT4, the insulin regulated glucose transporter, leading to improved insulin sensitivity and decreased glucose production by about 20%.13
References
1. Hamilton MT, Healy GN, Dunstan DW, Zderic TW, Owen N. Too little exercise and too much sitting: Inactivity physiology and the need for new recommendations on sedentary behavior. Current cardiovascular risk reports. 2008;2:292-298.
2. Yang EJ, Kerver JM, Park YK, Kayitsinga J, Allison DB, Song WO. Carbohydrate intake and biomarkers of glycemic control among us adults: The third national health and nutrition examination survey (nhanes iii). The American Journal of Clinical Nutrition. 2003;77:1426- 1433.
3. Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential. Biochimica et Biophysica Acta (BBA)-General Subjects. 2009;1790:1149-1160.
4. Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Hormone and metabolic research. 2004;36:119-125.
5. Sheng X, Zhang Y, Gong Z, Huang C, Zang YQ. Improved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator-activated receptors. PPAR research. 2008;2008.
6.Doisy R, Streeten D, Freiberg J, Schneider A. Chromium metabolism in man and biochemical effects. Trace Elements in Human Health and Disease. 2013;2:79-104.
7. Mertz W. The interaction between chromium and insulin. Nutrition, Digestion, Metabolism: Proceedings of the 28th International Congress of Physiological Sciences, Budapest, 1980. 2013:101.
8.Anderson RA, Cheng N, Bryden NA, Polansky MM, Cheng N, Chi J, Feng J. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes. 1997;46:1786-1791.
9.Kim K-H. Regulation of mammalian acetyl-coenzyme a carboxylase. Annual Review of Nutrition. 1997;17:77-99.
10. Baumgartner E, Suormala T. Multiple carboxylase deficiency: Inherited and acquired disorders of biotin metabolism. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin-und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 1996;67:377-384.
11.Albarracin CA, Fuqua BC, Evans JL, Goldfine ID. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes/metabolism research and reviews. 2008;24:41-51.
12. Matschinsky FM. Regulation of pancreatic β-cell glucokinase from basics to therapeutics. Diabetes. 2002;51:S394-S404.
13.Cohen N, Halberstam M, Shlimovich P, Chang CJ, Shamoon H, Rossetti L. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. The Journal of Clinical Investigation. 1995;95:2501.
