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Mighty Methylfolate - 60 Count Modern Endocrine
Mighty Methylfolate - 60 Count Modern Endocrine

Mighty Methylfolate - 60 Count

$41.00

Safe & Tested Ingredients

Dr. Formulated

Optimized For You

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Mighty Methylfolate is a highly concentrated folate as Quatrefolic® (100% 5-MTHF, the biologically active form of folate) with vitamins B2, B6 and B12 as methylcobalamin.

Clinical Applications

  • Supports Optimal Methylation (especially needed in MTHFR) and Cardiovascular Health
  • Increases Neurotransmitter Production (can assist in depression, anxiety, and insomnia)
  • Supports Primary Detoxification Pathways (can assist in autoimmune diseases)
  • Promotes Hormone Balance (can assist in low testosterone or high estrogen)
  • Promotes DNA Repair
  • Supports Healthy Homocysteine Levels

It is estimated that 60% of North Americans could have a gene mutation known as MTHFR (methylenetetrahydrofolate reductase). These people do not convert inactive folate to active folate (5-Methylenetetrahydrofolate (MTHF)) which leads to low active folate levels. This methylation process in the body is critical for supporting many aspects of mental and physical health including regulating gene expression. Methylation occurs billions of times every second and helps the body to repair DNA on a continual basis. However, when methylation processes in the body slow down, an increase in the breakage of DNA strands can occur. In addition to maintaining DNA repair, methylation reactions help maintain optimal neurotransmitter production, homocysteine balance for cardiovascular health, and the recycling of molecules that are required for detoxification and healthy inflammatory response. Methylation is also required for proper energy metabolism, immune and nerve cell function. Proper methylation can be inhibited by nutrient deficiencies including folate, and B2, B6 and B12. Certain medications such as acetaminophen, aspirin, ibuprofen and oral contraceptives or history of gastric bypass or gastric sleeve surgeries can also deplete blood levels of these crucial B vitamins.

Mighty Methylfolate provides high-concentration folate as Quatrefolic®- 100% 5-MTHF, the biologically active form, and trimethyl glycine. It also includes the key methylation vitamins B2, B6 and B12 (methylcobalamin). This specific blend of methyl donors promotes DNA repair, homocysteine balance, neurotransmitter production, hormone balance and optimal detoxification.

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Mighty Methylfolate - 60 Count

$41.00 USD

Clinical Grade Products

Formulated using clinically studied ingredients and produced under strict quality standards. Each of our products undergoes thorough review to guarantee safety, purity, and potency.

Cassie Smith, MD Approved

Cassie Smith, MD is dual board-certified in endocrinology, diabetes, metabolism, and internal medicine. She’s a certified health care professional who understands the power of high quality vitamin and supplement formulas. She has approved every selected ingredient to support your long term wellness.

Why Our Supplements Work

Expert-Selected

Expertly Curated

Every product is hand-selected by Dr. Cassie Smith and our team of medical professionals, rooted in science, not trends.

Compassionate Service

Compassionate Care

We prioritize your comfort, well-being, and long-term success with supplements designed to support real healing, not just symptom relief.

Holistic Approach

Whole-Body Wellness

We take a functional, holistic approach—pairing high-quality supplements with lifestyle guidance, nutrition support, and stress management.

Frequently Asked Questions

How should I store my supplements?

Most supplements should be kept in a cool, dry place away from direct sunlight. 

Are your supplements third-party tested?

Our manufacturer maintains a legacy of good manufacturing practices, instated long before cGMPs became compliance requirements. They stay up-to-date on industry research and testing methods,  and fine-tune their manufacturing  practices accordingly. They own and operate a cGMP, FDA-audited manufacturing and distribution facility here in the United States. The facility is equipped with high-performance HVAC and desiccant control that maintains ideal manufacturing conditions. Their staff are highly trained personnel who share a passion for efficacy. Because they control the entire production process—from formulation, raw material sourcing, and manufacturing, to laboratory testing of incoming materials and finished products, to bottling and labeling—they are free to be perfectionists. Their manufacturing facility is strictly controlled by rigorous standards that  meet cGMPs, and it routinely passes FDA and third-party audits. Extensive testing  on every lot they manufacture means you can trust the consistent purity, strength, identity and composition of each and every product formula.

Do you ship internationally?

Currently we only ship inside the United States.

What is your return policy? 

We accept returns on unopened products within 30 days of purchase. Please see our full return policy here

When are orders shipped?

Orders are typically shipping out the next business day.  Weather events or holidays can affect processing time. Customers will receive an email with tracking upon their order processing.

Still need help? 

Please visit or contact page here

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