{"title":"BFCM 25","description":null,"products":[{"product_id":"dim-elite-cdg-60-ct-me","title":"DIM Elite CDG - 90 CT ME","description":"\u003ch3 dir=\"ltr\"\u003eDIM Elite CDG\u003c\/h3\u003e\n\u003ch4 dir=\"ltr\"\u003eClinical Applications\u003c\/h4\u003e\n\u003cul dir=\"ltr\"\u003e\n\u003cli\u003eSupports healthy estrogen balance (may be useful in PCOS, PMS, PMDD and hormonal acne)\u003c\/li\u003e\n\u003cli\u003eSupports proper estrogen metabolism in women and men (may be useful in women or men over 40 with a natural decline in estrogen clearance)\u003c\/li\u003e\n\u003cli\u003eSupports healthy aromatase activity and free or active testosterone, meaning less conversion of testosterone to estrogen (may be useful alongside hormone replacement therapy)\u003c\/li\u003e\n\u003cli\u003eSupports estrogen detoxification pathways (inhibits beta-glucuronidase, supporting the clearance of estrogens, foreign molecules and fat-soluble toxins)\u003c\/li\u003e\n\u003cli\u003eSupports a favorable estrogen metabolite profile (increases protective 2-OHE relative to higher-risk 4-OHE and 16α-OHE)\u003c\/li\u003e\n\u003cli\u003eSupports healthy insulin signalling and ovarian function with 700 mg inositol\u003c\/li\u003e\n\u003cli\u003eProvides cellular antioxidant support with vitamin E (as d-alpha tocopheryl succinate)\u003c\/li\u003e\n\u003cli\u003eA strong foundational consideration for patients on HRT\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 dir=\"ltr\"\u003eFormula (per 3-capsule serving)\u003c\/h4\u003e\n\u003cp dir=\"ltr\"\u003eCalcium D-Glucarate 1 g · Inositol 700 mg · Indole-3-Carbinol 200 mg · 3,3′-Diindolylmethane (DIM) 100 mg · Vitamin E 33.5 mg (as d-alpha tocopheryl succinate, 223% DV)\u003c\/p\u003e\n\u003ch4 dir=\"ltr\"\u003eOverview\u003c\/h4\u003e\n\u003cp dir=\"ltr\"\u003eEstrogen collectively refers to the female hormones estrone (E1), estradiol (E2) and estriol (E3). Estrogen is an important hormone messenger that interacts with cells throughout the body, most notably breast and prostate tissues. The most important message it delivers to cells is to grow, divide and multiply. For this reason, hormones (especially estrogen) are critically important in human development and tissue repair. Supporting proper estrogen synthesis, metabolism and detoxification is essential for proper hormonal balance.\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003eDIM Elite CDG is a targeted supplement that combines the cruciferous vegetable metabolites indole-3-carbinol (I3C) and 3,3′-diindolylmethane (DIM) with calcium D-glucarate (CDG) to support balanced estrogen metabolism. The formula also includes inositol for insulin and ovarian signalling, and vitamin E for antioxidant protection. Formulating I3C and DIM together creates a complementary combination of metabolites that work together to support estrogen balance and breast and prostate health.¹⁻⁴ However, estrogen’s proliferative effects must be balanced and controlled for optimal health. To ensure proper hormonal balance, estrogen synthesis and detoxification should be supported, as estrogen has several downstream metabolites, some of which are beneficial while others have potentially harmful biological activity.\u003c\/p\u003e\n\u003ch4 dir=\"ltr\"\u003eI3C and DIM\u003c\/h4\u003e\n\u003cp dir=\"ltr\"\u003ePreclinical data on I3C and DIM suggest that these phytonutrient metabolites have a strong potential for supporting breast, cervical, endometrial and prostate health. Together, I3C and DIM promote metabolism toward the more favorable and protective estrogen metabolite, 2-hydroxyestrone (2-OHE), rather than the less favorable 4-hydroxyestrone (4-OHE) and 16α-hydroxyestrone (16α-OHE).⁵,⁶ In contrast to 2-OHE, both 4-OHE and 16α-OHE have been shown to overstimulate cells and generate free radicals that contribute to DNA damage.⁷,⁸ Several human supplementation studies in both male and female subjects consistently show that urinary levels of 2-OHE, and the ratio of 2-OHE to 16α-OHE, increase following supplementation with I3C.⁵,⁶,⁹⁻¹¹ This increase is advantageous, as the 2-OHE to 16α-OHE ratio is a marker of a more favorable estrogen metabolite profile.\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003eBoth I3C and DIM have also been shown in vitro to decrease expression of aromatase, the enzyme that converts androgens to estrogen.¹²\u003c\/p\u003e\n\u003ch4 dir=\"ltr\"\u003eCalcium D-Glucarate\u003c\/h4\u003e\n\u003cp dir=\"ltr\"\u003eCalcium D-glucarate is the supplemental calcium salt form of D-glucaric acid, a substance produced naturally in the body and obtained through certain fruits and vegetables. Calcium D-glucarate has been extensively studied and shown to inhibit beta-glucuronidase, an enzyme produced by certain bacteria in the gut. When beta-glucuronidase activity is high, estrogens that the liver has already conjugated for excretion can be uncoupled and reabsorbed. Inhibiting it supports the body’s ability to clear estrogens, foreign molecules and fat-soluble toxins.¹³⁻¹⁵ DIM Elite CDG provides a full 1 g per serving.\u003c\/p\u003e\n\u003ch4 dir=\"ltr\"\u003eInositol\u003c\/h4\u003e\n\u003cp dir=\"ltr\"\u003eInositol acts as a second messenger in insulin signalling and in the signalling of follicle-stimulating hormone (FSH) in the ovary. Supplementation has been studied for its support of insulin sensitivity, ovarian function and menstrual regularity, particularly in women with PCOS.[REF] Because insulin and estrogen metabolism are closely linked, 700 mg of inositol extends the formula’s support to the metabolic side of hormonal balance.\u003c\/p\u003e\n\u003ch4 dir=\"ltr\"\u003eVitamin E\u003c\/h4\u003e\n\u003cp dir=\"ltr\"\u003eVitamin E is the body’s primary fat-soluble antioxidant, protecting cell membranes from lipid peroxidation. DIM Elite CDG provides 33.5 mg as d-alpha tocopheryl succinate (223% DV), a natural-source, stable form of vitamin E, to provide antioxidant support alongside estrogen metabolism.[REF]\u003c\/p\u003e\n\u003ch4 dir=\"ltr\"\u003eSuggested Use\u003c\/h4\u003e\n\u003cp dir=\"ltr\"\u003e3 capsules per day or as recommended by your healthcare professional.\u003c\/p\u003e\n\u003ch4 dir=\"ltr\"\u003eCaution\u003c\/h4\u003e\n\u003cp dir=\"ltr\"\u003eDo not consume if pregnant or nursing. Manufactured in a facility that processes milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soybeans and sesame.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Modern Endocrine","offers":[{"title":"Default Title","offer_id":45330369511524,"sku":"M0KTZN5NRC","price":60.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0694\/9001\/6356\/files\/ModernEndocrineSupplementBottlewithCapsules.png?v=1793038761"},{"product_id":"mighty-methylfolate-60-count","title":"Mighty Methylfolate - 60 Count","description":"\u003cp\u003e\u003cstrong\u003eMighty Methylfolate is a highly concentrated folate as Quatrefolic® (100% 5-MTHF, the biologically active form of folate) with vitamins B2, B6 and B12 as methylcobalamin.\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical Applications\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv\u003e\n\u003cul\u003e\n\u003cli\u003eSupports Optimal Methylation (especially needed in \u003cstrong\u003eMTHFR\u003c\/strong\u003e) and Cardiovascular Health\u003c\/li\u003e\n\u003cli\u003eIncreases Neurotransmitter Production (can assist in \u003cstrong\u003edepression, anxiety, and insomnia\u003c\/strong\u003e)\u003c\/li\u003e\n\u003cli\u003eSupports Primary Detoxification Pathways (can assist in \u003cstrong\u003eautoimmune diseases\u003c\/strong\u003e)\u003c\/li\u003e\n\u003cli\u003ePromotes Hormone Balance (can assist in \u003cspan style=\"background-color: initial;\"\u003e\u003cstrong\u003elow testosterone or high estrogen\u003c\/strong\u003e\u003c\/span\u003e)\u003c\/li\u003e\n\u003cli\u003ePromotes DNA Repair\u003c\/li\u003e\n\u003cli\u003eSupports Healthy Homocysteine Levels\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eIt is estimated that 60% of North Americans could have a gene mutation known as MTHFR (methylenetetrahydrofolate reductase). These people do not convert inactive folate to active folate (5-Methylenetetrahydrofolate (MTHF)) which leads to low active folate levels.\u003c\/strong\u003e This methylation process in the body is critical for supporting many aspects of mental and physical health including regulating gene expression. Methylation occurs billions of times every second and helps the body to repair DNA on a continual basis. However, when methylation processes in the body slow down, an increase in the breakage of DNA strands can occur. In addition to maintaining DNA repair, methylation reactions help maintain optimal neurotransmitter production, homocysteine balance for cardiovascular health, and the recycling of molecules that are required for detoxification and healthy inflammatory response. Methylation is also required for proper energy metabolism, immune and nerve cell function. Proper methylation can be inhibited by nutrient deficiencies including folate, and B2, B6 and B12. \u003cstrong\u003eCertain medications such as acetaminophen, aspirin, ibuprofen and oral contraceptives or history of gastric bypass or gastric sleeve surgeries can also deplete blood levels of these crucial B vitamins.\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003eMighty Methylfolate\u003c\/strong\u003e provides high-concentration folate as Quatrefolic®- 100% 5-MTHF, the biologically active form, and trimethyl glycine. It \u003cstrong\u003ealso includes the key methylation vitamins B2, B6 and B12 (methylcobalamin)\u003c\/strong\u003e. This specific blend of methyl donors \u003cstrong\u003epromotes DNA repair, homocysteine balance, neurotransmitter production, hormone balance and optimal detoxification\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSuggested Use: \u003c\/strong\u003e1 capsule per day or as recommended by your health care professional.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Modern Endocrine","offers":[{"title":"Default Title","offer_id":45330370429028,"sku":"KD8DA82QKV","price":44.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0694\/9001\/6356\/files\/Mighty-Slide-1.jpg?v=1772037189"}],"url":"https:\/\/shopmodernendocrine.com\/collections\/bfcm-25.oembed","provider":"Modern Endocrine","version":"1.0","type":"link"}